Occupy EGFR: Figure 1.

Occupy EGFR.

Erlotinib and gefitinib inhibit the growth of non-small cell lung cancer tumors that harbor activating epidermal growth factor receptor (EGFR) mutations but are ineffective against EGFR variants found in glioblastoma. New studies by Barkovich and colleagues and Vivanco and colleagues show that these drugs only occupy the active sites of glioblastoma-derived EGFR mutants to a limited extent and ...

Web Figure 1

Occupy tissue

The critical role of migration and invasion in cancer metastasis warrants new therapeutic approaches targeting the machinery regulating cell migration and invasion. While 2-dimensional (2D) models have helped identify a range of adhesion molecules, cytoskeletal components and regulators that are potentially important for cell migration, the use of models that better mimic the 3-dimensional (3D)...

P Figure 1: Lookup Table Figure 2: Decomposition

a t t e r n T h e o r e t i c L e a r n i n g Abstract The goal of learning from sample data is to extract a concept that captures the underlying pattern while still representing it in a way useful to the investigator. A new approach based on function decomposition in the Pattern Theory framework is presented here. The objective of this extended abstract is threefold. The rst is to provide an o...

Theory in Biology: Figure 1 or Figure 7?

The pace of modern science is staggering. The quantities of data now flowing from DNA sequencers, fluorescence and electron microscopes, mass spectrometers, and other mind-blowing instruments leave us faced with information overload. This explosion in data has brought on its heels a concomitant need for efforts at the kinds of synthesis and unification we see in theoretical physics. Often in ce...